| Autor: |
Khan SN; Centre for Applied Molecular Biology, University of the Punjab, Thokar Niaz Baig, Lahore, Pakistan. snkhan52@hotmail.com, Hasan F, Sollaino C, Perseu L, Riazuddin S |
| Jazyk: |
angličtina |
| Zdroj: |
Hemoglobin [Hemoglobin] 2003 Aug; Vol. 27 (3), pp. 161-6. |
| DOI: |
10.1081/hem-120023379 |
| Abstrakt: |
Common alpha-thalassemia (thal) rearrangements were studied in a normal random population and in six ethnic groups of Pakistan. Analyses of 204 individuals from the normal population revealed the presence of only the -alpha(3.7) allele with an overall frequency of 8.3%. Ethnic differences were statistically significant for Pashtoon vs. Balochi (p < 0.0005) and Pashtoon vs. Sindhi (p < 0.002). Two hundred and eighty-five thalassemia patients were also studied to identify rare alpha-thal alleles. In this group, 24.6% of the patients had one or two alpha genes deleted. Two rare alleles in the Pakistani population, -alpha(4.2) (0.2%) and alphaalphaalpha(anti3.7) (0.9%), were identified in these patients. The -alpha(4.2) allele was found only in Sindhis, while alphaalphaalpha(anti3.7) was present in Punjabis, Sindhis and Balochis. Five patients with triplicated alpha genes were homozygous for either the beta+ or the beta(0) genotype. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
