| Autor: |
de Paula CD; Serviço de Dermatologia, Hospital Universitário de Brasília, Brasília, DF, Brasil. rnrsampaio@hotmail.com, Sampaio JH, Cardoso DR, Sampaio RN |
| Jazyk: |
portugalština |
| Zdroj: |
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2003 May-Jun; Vol. 36 (3), pp. 365-71. Date of Electronic Publication: 2003 Jul 31. |
| Abstrakt: |
Seventy-nine patients with cutaneous leishmaniasis were included in this study. The experimental group (n = 38) was treated with pentamidine isothionate in a dose of 4mg/kg/day on alternate days, for one week. The control group (n = 41) was treated with N-methylglucamine in a dose of 20mgSbV/kg/day for 20 days. Twenty-one isolates were identified using monoclonal antibody technique. We characterized Leishmania (Viannia) braziliensis, most frequently. There was a cure rate of 71.05% of the patients in the experimental group and 73.17% in the control group (p = 0.47). We found a statistical significance regarding frequency of ECG alterations between the experimental and control group (p<0.05). In our study pentamidine was as effective as antimonial for the treatment of american cutaneous leishmaniasis. It proved to be a safer drug considering heart toxicity. Moreover, it requires less time to complete the treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
