| Autor: |
Capitosti SM; Department of Chemistry, University of Virginia, P.O. Box 400319, Charlottesville, Virginia 22904, USA., Hansen TP, Brown ML |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2003 Aug 07; Vol. 5 (16), pp. 2865-7. |
| DOI: |
10.1021/ol034906w |
| Abstrakt: |
[reaction: see text] A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of thalidomide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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