| Autor: |
Kruger EF; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Spring Street, Mississippi State, MS 39762-6100, USA., Boyd BL, Pinchuk LM |
| Jazyk: |
angličtina |
| Zdroj: |
Developmental and comparative immunology [Dev Comp Immunol] 2003 Dec; Vol. 27 (10), pp. 889-97. |
| DOI: |
10.1016/s0145-305x(03)00080-6 |
| Abstrakt: |
Although a role for monocytes and monocyte-derived dendritic cells (DC) in the activation of T cells is well established, it is less clear to what extent DC and their precursors, monocytes, regulate B cell immune responses. Here we show that regulatory mechanisms similar to those in humans are in place in the bovine immune system. In vitro culture of bovine monocytes with bovine B cells activated by the anti-CD3 triggered CD4+ T cells or through immunoglobulin (Ig) receptor crosslinking induces B cell Ig secretion. Unlike bovine monocyte-derived DC, monocytes do not promote Ig class switching to IgG and IgA in activated peripheral blood B cells. These results suggest that bovine monocytes are capable of directly inducing Ig secretion in activated bovine peripheral blood B cells, but do not provide the signals for B cell Ig class switching. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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