| Autor: |
Bhatia PS; Department of Dermatology, B.R.D. Medical College, Gorakhpur, India., Mohan L, Pandey ON, Singh KK, Arora SK, Mukhija RD |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of dermatological science [J Dermatol Sci] 1992 Nov; Vol. 4 (3), pp. 180-4. |
| DOI: |
10.1016/0923-1811(92)90017-6 |
| Abstrakt: |
Four hundred vitiligo patients and 100 non-vitiliginous controls were studied to find out the prevalence of vitiligo in relatives of patients and controls. The difference was found to be statistically highly significant. The data reflected that there is some genetic mechanism involved in the etiology of vitiligo. Respective relatives of all forms of the disease in the vitiligo group showed a clear preponderance compared to controls. There was clustering of affected relatives in vitiligo cases compared to controls. The ratio of affected and unaffected siblings with unaffected parents or one parent affected, the ratio in the children of probands, the ratio in children of affected paternal and maternal grandparents of probands, suggest the polygenic nature of vitiligo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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