| Autor: |
Ingman K; Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland. kiming@utu.fi, Salvadori S, Lazarus L, Korpi ER, Honkanen A |
| Jazyk: |
angličtina |
| Zdroj: |
Addiction biology [Addict Biol] 2003 Jun; Vol. 8 (2), pp. 173-9. |
| DOI: |
10.1080/1355621031000117400 |
| Abstrakt: |
We studied the effect of a novel delta-opioid receptor antagonist N,N(CH(3))(2)Dmt-Tic-OH (Me(2)-Dmt-Tic-OH) on voluntary ethanol intake in an alcohol-preferring AA (Alko, Alcohol) rat line using a 4-hour limited access paradigm. Acute injections of Me(2)-Dmt-Tic-OH (10 and 30 mg/kg, i.p.) did not reduce 1-hour or 4-hour ethanol intake. Subtype non-selective opioid receptor antagonist naltrexone [0.1 and 0.3 mg/kg, subcutaneously (s.c.)] significantly reduced 1-hour ethanol drinking but had no effect on 4-hour ethanol consumption. Locomotor stimulation induced by the delta-opioid receptor agonist Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE; 15 microg, intracerebroventricularly) was significantly attenuated by Me(2)-Dmt-Tic-OH (10 and 30 mg/kg, i.p.), which confirmed its efficacy as a delta-opioid receptor antagonist in rat brain. Our results support the idea that delta-opioid receptors do not mediate alcohol reward in AA rats. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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