| Autor: |
Hirata AE; Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, FCM-UNICAMP, 13081-970 Campinas, SP, Brazil., Alvarez-Rojas F, Carvalheira JB, Carvalho CR, Dolnikoff MS, Abdalla Saad MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Life sciences [Life Sci] 2003 Aug 01; Vol. 73 (11), pp. 1369-81. |
| DOI: |
10.1016/s0024-3205(03)00477-6 |
| Abstrakt: |
PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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