| Autor: |
Ries UJ; Department of Chemical Research, Boehringer Ingelheim Pharma KG, Birkendorfer Strasse 65, D-88397, Biberach/Riss, Germany. uwe.ries@bc.boehringer-ingelheim.com, Priepke HW, Hauel NH, Haaksma EE, Stassen JM, Wienen W, Nar H |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Jul 21; Vol. 13 (14), pp. 2291-5. |
| DOI: |
10.1016/s0960-894x(03)00442-6 |
| Abstrakt: |
Amidino-phenoxy quinoline derivatives represent a new class of potent thrombin inhibitors with good selectivity and remarkably low molecular weight (M(W): 335-391). X-ray analyses of thrombin-bound inhibitors revealed that enzyme inhibition is mainly based on hydrophobic interactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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