| Autor: |
Lebedev LR; Vector State Research Center of Virology and Biotechnology, Ministry of Health of the Russian Federation, Kol'tsovo, Novosibirsk Oblast, 633159 Russia. llr@ngs.ru, Goncharova EP, Sizov AA, Bulychev LE, Odegov AM, Ryzhikov AB |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2003 May-Jun; Vol. 37 (3), pp. 544-9. |
| Abstrakt: |
A method was elaborated to construct combined artificial immunogens mimicking virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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