| Autor: |
Petre J; SmithKline Beecham Biologicals, Rixensart, Belgium., Rutgers T, Hauser P |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of virology. Supplementum [Arch Virol Suppl] 1992; Vol. 4, pp. 137-41. |
| DOI: |
10.1007/978-3-7091-5633-9_30 |
| Abstrakt: |
Yeast cells have been engineered to express mixed HBsAg particles containing the S and a modified large (L*) protein. Their construction resulted in reduced protease sensitivity, reduced glycosylation and complete inactivation of the polymerized human albumin binding site. The particles exposed the S, preS1 and preS2 antigenic determinants and induced an immune response against the three domains. Highly purified preparations have been obtained and are presently being tested in human volunteers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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