| Autor: |
Mansour AA; Division of Basic Medical Sciences, Memorial University, St. John's, Newfoundland, Canada., Babstock DM, Penney JH, Martin GM, McLean JH, Harley CW |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioral neuroscience [Behav Neurosci] 2003 Jun; Vol. 117 (3), pp. 621-31. |
| DOI: |
10.1037/0735-7044.117.3.621 |
| Abstrakt: |
Idazoxan, an alpha 2 adrenoceptor antagonist (2 mg/kg), enhanced novel object investigation in a holeboard in rats as previously reported (V. Devauges & S. J. Sara, 1990). Two weeks of 10 min/day in 37 degrees C water increased dopamine-beta-hydroxylase staining density in the locus coeruleus but did not enhance novel object investigation. In contrast to idazoxan, however, the warm water treatment increased rearing, center entries, and activity, a pattern previously described during tonic infusion of norepinephrine into the hippocampus. Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations. The behavioral effects across the idazoxan and warm water experiments support G. Aston-Jones et al.'s (1999) 2 modes of attention hypothesis for locus coeruleus function: Phasic locus coeruleus activity promotes focused attention; tonic locus coeruleus activity promotes scanning attention. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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