| Autor: |
Novince ZM; Department of Biology, University of Akron, Akron, OH 44325-3908, USA., Azodi E, Marrs JA, Raymond PA, Liu Q |
| Jazyk: |
angličtina |
| Zdroj: |
Gene expression patterns : GEP [Gene Expr Patterns] 2003 Jun; Vol. 3 (3), pp. 337-9. |
| DOI: |
10.1016/s1567-133x(03)00030-9 |
| Abstrakt: |
Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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