| Autor: |
Bershteĭn DM; N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg., Chernobrovkina AE, Gamaiunova VB, Tsyrlina EV, Kvachevskaia IuO, Kovalenko IG |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy onkologii [Vopr Onkol] 2003; Vol. 49 (2), pp. 152-5. |
| Abstrakt: |
Late-onset of menopause is a marker of risk factor for neoplasia in the reproductive system and, conversely, anti-risk for certain non-infectious diseases, such as cardio-vascular disease or osteoporosis. We studied 118 postmenopausal patients with early endometrial and breast cancers. The investigation was particularly concerned with hormonal-metabolic status versus age at menopause age at. While a Quetelet index/age was irrelevant, blood cholesterol and insulin (120 min) concentrations and tumor estrogen/progesterone receptor ratios were relatively higher in the late-onset group ((52 yrs). This group showed a correlation with age at menopause while the other one--with its duration. Insulin/body weight ratios were higher in the late-onset group while LH/FSH--lower. Hence, patients of the same age but differing in age at menopause age at may show differences in hormonal-metabolic status as well. This feature may be significant in identifying both biological distinctions of associated tumors and their clinical course. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
