[Effect of thyrocalcitonin on the recovery processes in adrenaline lesion of the myocardium].

Autor: Sokolov IK, Belen'kiĭ EE, Tunitskaia TA, Kalugina GE, Briskin AI
Jazyk: ruština
Zdroj: Farmakologiia i toksikologiia [Farmakol Toksikol] 1976 Mar-Apr; Vol. 39 (2), pp. 167-73.
Abstrakt: Administration of thyrocalcitonine (TCT) in doses of 0.1 and 1 Un/kg for 14 days prevented the development of myocarditis in rats receiving epinephrine (3 mg/kg) for 4 days reduced the death rate among the animals, increased their body weight and normalized the electrolytes composition in the heart. Given in a dose of 10 Un/kg the drug produced a less pronounced positive effect on the study values in the animals with experimentally-produced epinephrine lesion of the heart. According to the authors this may be occasioned by an intensified secretion of the parathyroid hormone in response to a multiple introduction of large TCT doses to the animals.
Databáze: MEDLINE