| Autor: |
Rudo ND, Lawrence AM, Rosenberg IH |
| Jazyk: |
angličtina |
| Zdroj: |
Gastroenterology [Gastroenterology] 1975 Dec; Vol. 69 (6), pp. 1265-8. |
| Abstrakt: |
Everted intestinal rings from partially starved rats accumulate the nonmetabolized amino acid 1-amino-cyclopentane-5-carboxylic acid (ACPC) at an enhanced rate. Plasma glucagon concentrations were found to be markedly elevated in these partially starved rats as well as in rats with experimentally induced diabetes, a condition previously shown to be associated with augmented intestinal uptake of amino acid. Treatment of partially starved rats with repeated injections of glucagon-binding antiserum prevented increased ACPC uptake of intestinal rings. Chronically elevated plasma glucagon levels may participate in the mechanism of the functional changes in the intestine in partial starvation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
