| Autor: |
Huang X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Anderson KW, Zim D, Jiang L, Klapars A, Buchwald SL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2003 Jun 04; Vol. 125 (22), pp. 6653-5. |
| DOI: |
10.1021/ja035483w |
| Abstrakt: |
The first general method for the Pd-catalyzed amination of aryl tosylates and benzenesulfonates was developed utilizing ligand 1, which belongs to a new generation of biaryl monophosphine ligands. In addition, the new catalyst system for the first time enables amidation of aryl arenesulfonates and aqueous amination protocols that do not necessitate the use of cosolvents. The substrate scope has been significantly expanded to include aryl halides containing primary amides and free carboxylic acid groups. In the case of multifunctional substrates, the Pd-catalyzed amination can provide selectivity that is complementary to the Cu-catalyzed C-N bond-forming processes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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