| Autor: |
Chaperon F; Nervous System Research, Novartis Pharma AG, S-386.3.32, Postfach, CH-4002, Basel, Switzerland. frederique.chaperon@novartis.pharma.com, Tricklebank MD, Unger L, Neijt HC |
| Jazyk: |
angličtina |
| Zdroj: |
Neuropharmacology [Neuropharmacology] 2003 Jun; Vol. 44 (8), pp. 1047-53. |
| DOI: |
10.1016/s0028-3908(03)00113-8 |
| Abstrakt: |
The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390, a selective D(1) receptor antagonist, and by L-741,626, a selective D(2) receptor antagonist. Moreover, the selective D(2) receptor agonist trihydroxy-N-n-propylnoraporphine (TNPA) elicited a robust hypothermia which was prevented by pretreatment with L-741,626 but not by A-437203. In agreement with previous data obtained in D(3) knock-out mice, present results suggest that D(2) rather than D(3) receptors mediate dopamine receptor agonist-induced hypothermia in rats. In addition, it appears that both D(1) and D(2) receptors may be involved in a cooperative manner. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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