| Autor: |
Mukhina TV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Oblast. mukhina@ipac.ac.ru, Lermontova NN, Van'kin GI, Oettel' M, Pachev VK, Bachurin SO |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2003 Mar-Apr; Vol. 53 (2), pp. 208-14. |
| Abstrakt: |
A chronic deprivation of brain cholinergic functions in rats caused by intracerebroventricular injection of neurotoxin AF64A increases the escape latency in Morris water maze test as compared to control sham-operated animals. Measurements and analysis of rat movement tracks using an original computerized "Behavioral Vision" system revealed the ability of 17 beta-Estradiol and its synthetic isomer J-861 (both administered daily in per os dose 0.2 mg/kg during 7 days before and 10 days after a single intracerebroventricular injection of AF64A) to improve learning of the animals. Directivity of search trajectories was estimated by a novel index of track straightness. The introduction of an index of "passive swimming" made it possible to reveal episodes of immobility in water-maze behavior of AF64A-injected animals. Unlike J-861, 17 beta-Estradiol almost completely eliminated these episodes. The newly developed indices (especially straightness) seem to be very useful in differentiating learning ability of rats from a decrease in their mobility in the Morris water-maze test, in particular, in case of the estrogens under study. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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