| Autor: |
Rodrigues Júnior JM; Laboratory of Pharmaceutical Technology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. jmrj@rdbiotec.com.br, de Melo Lima K, de Matos Jensen CE, de Aguiar MM, da Silva Cunha Júnior A |
| Jazyk: |
angličtina |
| Zdroj: |
Artificial organs [Artif Organs] 2003 May; Vol. 27 (5), pp. 492-7. |
| DOI: |
10.1046/j.1525-1594.2003.07244.x |
| Abstrakt: |
In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 microm. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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