Endovascular therapy combined with immunosuppressive treatment for pseudoaneurysms in patients with Behçet's disease.
| Autor: | Kwon Koo B; Division of Cardiology, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Seoul, Korea., Shim WH, Yoon YS, Kwon Lee B, Choi D, Jang Y, Lee DY, Chang BC |
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| Jazyk: | angličtina |
| Zdroj: | Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists [J Endovasc Ther] 2003 Feb; Vol. 10 (1), pp. 75-80. |
| DOI: | 10.1177/152660280301000116 |
| Abstrakt: | Purpose: To evaluate the feasibility, efficacy, and outcome of endovascular therapy combined with immunosuppression for the treatment of arterial pseudoaneurysms due to Behçet's disease. Methods: Eleven pseudoaneurysms (3 in the abdominal aorta, 3 in the subclavian artery, and individual lesions in the brachiocephalic artery, renal artery, common iliac artery, common carotid artery, and the descending thoracic aorta) in 9 patients with Behçet's disease were treated with 10 stent-grafts and 1 self-expanding stent. All patients with elevated erythrocyte sedimentation rate (ESR) were treated with immunosuppressive agents (azathioprine, prednisolone) before and after the procedure. Results: Endovascular treatment was successful in all cases, without major adverse events. The ESR was reduced from 42.7+/-18.0 mm/h initially to 18.6+/-12.6 mm/h after immunosuppressive therapy prior to endovascular repair. During follow-up (mean 24.1+/-14.0 months, range 6-43), 8 of 11 lesions showed complete resolution. One stent-graft to treat a postsurgical recurrent carotid artery pseudoaneurysm was occluded, and an abdominal aortic pseudoaneurysm recurred; both patients stopped their medications. ESR during follow-up was 7.9+/-4.5 mm/h. Conclusions: Endovascular treatment for pseudoaneurysms due to Behçet's disease is feasible and effective when disease activity is strictly controlled with immunosuppressive therapy. |
| Databáze: | MEDLINE |
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