| Autor: |
Varrot A; Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, UK Y010 5YW., Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2003 Apr 21 (8), pp. 946-7. |
| DOI: |
10.1039/b301592k |
| Abstrakt: |
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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