| Autor: |
Zakai HA; Medical Technology Program, Faculty of Medicine and Allied Sciences, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia. haythamzakai@yahoo.com, Zimmo SKh, Fouad MA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the Egyptian Society of Parasitology [J Egypt Soc Parasitol] 2003 Apr; Vol. 33 (1), pp. 97-107. |
| Abstrakt: |
The antiproliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major, L. donovani and L. mexicana promastigotes are reported. Treatment of promastigotes cultures with itraconazole or with terbinafine induced growth arrest with L. major but neither with L. donovani nor with L. mexicana. Concentrations of 0.75 microl/l or more of itraconazole induced cell lysis after 72 hours with L. major. However, even relatively large concentrations of terbinafine (2.0 microl/l) did not induce cell lysis. For L. major, the IC 50 for itraconazole and terbinafine were 0.31 microl/l and 3.3 microl/l respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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