Lewis rat model of chronic renal allograft rejection. Ten days after allogeneic kidney transplantation, rats were equipped with telemetry transmitters for continuous monitoring of blood pressure. Urine was sampled 24, 96 and 180 days after kidney transplantation for measurement of renal protein loss and excretion of nitric oxide metabolites. Proteinuria increased with time after transplantation, while urinary excretion of nitric oxide metabolites declined. In five of six rats blood pressure remained in the normotensive range, and its 24-h pattern was preserved up to 6 months post-transplantation. One animal showed hypertensive blood pressure and a disturbed 24-h pattern with peak values during the rest period. In the post-mortem analysis this rat showed a hydronephrotic kidney graft. In conclusion, blood pressure and its 24-h pattern are preserved after successful allogeneic kidney transplantation in the rat.
| Entry Date(s): |
Date Created: 20030506 Date Completed: 20040106 Latest Revision: 20030505 |
| Update Code: |
20240829 |
| DOI: |
10.1007/s00147-002-0538-2 |
| PMID: |
12730805 |
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| Autor: |
Witte K; Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Maybachstrasse 14-16, 68169, Mannheim, Germany. klaus.witte@urz.uni-heidelberg.de, Braun C, Pummer S, Vetter S, Lemmer B |
| Jazyk: |
angličtina |
| Zdroj: |
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2003 Apr; Vol. 16 (4), pp. 250-6. Date of Electronic Publication: 2003 Feb 06. |
| DOI: |
10.1007/s00147-002-0538-2 |
| Abstrakt: |
We investigated long-term and circadian blood-pressure changes in a Fischer-->Lewis rat model of chronic renal allograft rejection. Ten days after allogeneic kidney transplantation, rats were equipped with telemetry transmitters for continuous monitoring of blood pressure. Urine was sampled 24, 96 and 180 days after kidney transplantation for measurement of renal protein loss and excretion of nitric oxide metabolites. Proteinuria increased with time after transplantation, while urinary excretion of nitric oxide metabolites declined. In five of six rats blood pressure remained in the normotensive range, and its 24-h pattern was preserved up to 6 months post-transplantation. One animal showed hypertensive blood pressure and a disturbed 24-h pattern with peak values during the rest period. In the post-mortem analysis this rat showed a hydronephrotic kidney graft. In conclusion, blood pressure and its 24-h pattern are preserved after successful allogeneic kidney transplantation in the rat. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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