Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives.

Autor: Jakubkiene V; Faculty of Chemistry, Vilnius University, Naugarduko 24, 2006, Vilnius, Lithuania. virginija.jakubkiene@chf.vu.lt, Burbuliene MM, Mekuskiene G, Udrenaite E, Gaidelis P, Vainilavicius P
Jazyk: angličtina
Zdroj: Farmaco (Societa chimica italiana : 1989) [Farmaco] 2003 Apr; Vol. 58 (4), pp. 323-8.
DOI: 10.1016/s0014-827x(02)00022-8
Abstrakt: The synthesis of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives and the results of anti-inflammatory activity in vivo are described. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than acetylsalicylic acid.
Databáze: MEDLINE
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