| Autor: |
Kors E; Department of Neurology, K5Q, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands., Haan J, Ferrari M |
| Jazyk: |
angličtina |
| Zdroj: |
Current pain and headache reports [Curr Pain Headache Rep] 2003 Jun; Vol. 7 (3), pp. 212-7. |
| DOI: |
10.1007/s11916-003-0075-4 |
| Abstrakt: |
The genetics of migraine is a fascinating and moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene in approximately 75% of the families. The finding of mutations in an ionchannel subunit defines migraine as a channelopathy (eg, epilepsy). The genetics of the more frequent variants, migraine with and without aura, is more complex. Several loci have been studied in families and case-control studies, but need to be confirmed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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