| Autor: |
Dell'Orfano J; University of Illinois College of Medicine, Chicago, Illinois, USA., Chou HA, Park D, Mirza H, Stys T, Mahan V, Zavitz DH, Petrikovsky BM, Ovadia M |
| Jazyk: |
angličtina |
| Zdroj: |
Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2003 Apr; Vol. 26 (4 Pt 1), pp. 805-11. |
| DOI: |
10.1046/j.1460-9592.2003.t01-1-00143.x |
| Abstrakt: |
Prenatal sudden cardiac death and hydrops fetalis are often due to complete heart block. However, no pacing modality exists for intrauterine application for fetal bradycardia. A prototype lead for a novel fetal pacemaker has been developed and used in a direct pacing model. It has been demonstrated that the lead can be safely and successfully deployed using a hypochondriac and transdiaphragmatic or subxiphoid approach. Pacing with ventricular capture was evident with the widening of QRS duration from 50.2 +/- 9.8 to 95.1 +/- 12.8 ms (P = 0.0001). Further studies by echocardiogram revealed an increase in the pulse with pacing, confirming pacing. This study documents proof-of-concept for closed thorax over-the-wire deployment of a novel lead design applicable to fetal pacing. By combining the lead design with microcircuitry and a small power source, it is possible to create a monolithic fetal pacemaker system capable of being deployed in utero. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
