Inhibition of human sperm acrosin by synthetic agents.

Autor: Bhattacharyya AK, Zaneveld LJ, Dragoje BM, Schumacher GF, Travis J
Jazyk: angličtina
Zdroj: Journal of reproduction and fertility [J Reprod Fertil] 1976 May; Vol. 47 (1), pp. 97-100.
DOI: 10.1530/jrf.0.0470097
Abstrakt: Twenty-two synthetic proteinase inhibitors were tested for their inhibitory properties towards human acrosin. p-Nitrophenyl-p1-guanidino benzoate (NPGB) was the most effective (K1 value of 1-5 X 10(-8) M), producing a non-competitive type of inhibition in contrast to all other inhibitors which showed a competitive type of inhibition. The Michaelis constant for human acrosin on BAEE at pH 8-1 was calculated to be 4-25 X 10(-5) M.
Databáze: MEDLINE