| Autor: |
Nawa H; Brain Research Institute, Niigata University., Futamura T, Mizuno M, Takahashi M, Toyooka K, Someya T |
| Jazyk: |
japonština |
| Zdroj: |
Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 2003 Mar; Vol. 61 (3), pp. 521-8. |
| Abstrakt: |
Abnormal development of the brain is implicated in the etiology and/or pathology of various psychiatric diseases, including schizophrenia. Current evidence indicates that neurotrophic factors can strongly influence neuronal phenotypic differentiation and subsequent neuronal function in synaptic plasticity. Among various neurotrophic factors, the expression of brain-derived neurotrophic factor(BDNF) and epidermal growth factor (EGF) is impaired in the brain as well as in the periphery of patients with schizophrenia. Based on this result, a novel animal model for schizophrenia has been established by perturbing the neurotrophic signaling during development. This review summarizes the latest progress of these studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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