| Autor: |
Chase TD; Department of Physiology and Biophysics, Dalhousie University, Halifax, NS B3 H 4H7, Canada B3J 3G9., Brown RE, Carrey N, Wilkinson M |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroreport [Neuroreport] 2003 Apr 15; Vol. 14 (5), pp. 769-72. |
| DOI: |
10.1097/00001756-200304150-00022 |
| Abstrakt: |
Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of long-term methylphenidate injections (one/day; 14 days) on immediate-early gene expression (c-fos) in the striatum of prepubertal male rats. Rats (25 days old) were injected once daily for 14 days with either saline or methylphenidate (1, 2 or 10 mg/kg), or for 13 days with saline followed by one injection of methylphenidate (1, 2 or 10 mg/kg) on day 14, and were sacrificed 2 h post-injection. Methylphenidate dose-dependently increased FOS immunoreactivity in the striatum. A single injection of methylphenidate (2 or 10 mg/kg) on day 14, following saline treatment for 13 days, caused a dramatic elevation in c-fos expression. This effect was significantly attenuated in animals treated chronically with methylphenidate (2 or 10 mg/kg) for the entire 14 days. Our data suggest that repeated methylphenidate treatment, at a clinically relevant dose (2 mg/kg), markedly inhibits immediate-early gene expression in the brain. This is the first demonstration of methylphenidate-induced modification of gene expression in developing rat striatum and may have implications for chronic methylphenidate use in children. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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