[Apolipoprotein E polymorphism as a predictor of progression of multiple sclerosis].

Autor:	Guerrero AL; Unidad de Neurología, Hospital Río Carrión, Palencia, Spain. aguerrerop@medynet.com, Bueno V, Hernández MT, Martín-Serradilla JI, Carrasco E, Cuadrado I
Jazyk:	Spanish; Castilian
Zdroj:	Neurologia (Barcelona, Spain) [Neurologia] 2003 Apr; Vol. 18 (3), pp. 146-8.
Abstrakt:	Introduction: During recent years, different studies have proposed that apolipoprotein E e4 can be a predictor of progression in multiple sclerosis. We aim to evaluate these findings in our country. Patients and Methods: We studied 42 patients with relapsing remitting or secondary progressive multiple sclerosis, and a disease duration of at least 2 years. We correlated the presence or absence of e4 allele with markers of progression such as age of onset and diagnosis, disease duration, number of relapses, EDSS at 1, 2, 5 and 10 years, progression index and relapse rate. Results: None of the parameters evaluated significantly correlate with e4 allele of the APOE. Conclusions: In spite of the limitation due to the small number of patients studied, we cannot confirm that APOE e4 allele is a predictor of progression of disability in multiple sclerosis.
Databáze:	MEDLINE
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