| Autor: |
Holla BS; Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, 574 199, Mangalagangothri, India. hollabs@yahoo.com, Malini KV, Rao BS, Sarojini BK, Kumari NS |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of medicinal chemistry [Eur J Med Chem] 2003 Mar; Vol. 38 (3), pp. 313-8. |
| DOI: |
10.1016/s0223-5234(02)01447-2 |
| Abstrakt: |
A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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