Digoxin-like immunoreactive substance in nonoliguric hyperkalemia of the premature infant.
| Autor: | Mildenberger E; Department of Pediatrics, Universitätsklinikum Benjamin Franklin, Berlin, Germany. eva.mildenberger@ukbf.fu-berlin.de, Oels K, Bauer K, Paul M, Versmold HT |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Biology of the neonate [Biol Neonate] 2003; Vol. 83 (3), pp. 182-7. |
| DOI: | 10.1159/000068929 |
| Abstrakt: | Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established. (Copyright 2003 S. Karger AG, Basel) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|