| Autor: |
Tapondjou LA; Department of Chemistry, Faculty of Science, University of Dschang, box, 183, Dschang, Cameroon., Lontsi D, Sondengam BL, Choi J, Lee KT, Jung HJ, Park HJ |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of pharmacal research [Arch Pharm Res] 2003 Feb; Vol. 26 (2), pp. 143-6. |
| DOI: |
10.1007/BF02976660 |
| Abstrakt: |
Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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