Consecutive allergen challenges resulted in decreased bronchial responsiveness.
| Autor: | He J; Respiratory Department, Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045, China., Jiang Z |
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| Jazyk: | angličtina |
| Zdroj: | Chinese medical journal [Chin Med J (Engl)] 2002 Nov; Vol. 115 (11), pp. 1727-9. |
| Abstrakt: | Objective: To investigate bronchial responsiveness to acetylcholine in allergic airway inflammation of SD rats. Methods: SD rats were immunized and challenged by chicken ovalbumin (OVA). Airway responsiveness, acetylcholine (Ach) provocation concentration needed to increase baseline airway resistance by 200% (PC(200)) were measured. Results: The value of baseline airway resistance in asthma group was significantly higher than that in control group (2.282 +/- 0.128 vs 3.193 +/- 0.239; P < 0.01). After multiple ovalbumin exposures, airway responsiveness to intravenous injection of acetylcholine decreased significantly (-LogPC(200): 4.006 +/- 0.554 vs 2.059 +/- 0.262; P < 0.01). Bronchial alveolar lavage fluid (BALF) and lung tissue specimen analysis indicated that airway allergic inflammation was present. Conclusions: The study demonstrates a dissociation between the bronchoconstrictor response and bronchial hyper-responsiveness and indicates that multiple ovalbumin exposures induces persistent bronchoconstriction with airway hypo-responsiveness despite airway allergic inflammation. |
| Databáze: | MEDLINE |
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