[Utility of verapamil in the treatment of diastolic dysfunction in patients with acromegaly].
| Autor: | Marín Ortuño F; Servicio de Cardiología, Hospital General Universitario de Alicante, Maestro Alonso 109, 03010 Alicante, Spain. fr.marino@coma.es, Climent Payá VE, Picó Alfonso AM, Martínez Martínez JG, Sánchez Payá J, Sogorb Garri F |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista clinica espanola [Rev Clin Esp] 2003 Jan; Vol. 203 (1), pp. 15-9. |
| DOI: | 10.1157/13042183 |
| Abstrakt: | Introduction: Diastolic dysfunction is a common complication in patients with acromegaly. By using the metabolic treatment for acromegaly, an improvement in diastolic function is not always achieved and a group of these patients could obtain some benefit from a specific treatment for such a condition. The objective of the present study was to evaluate the utility of verapamil therapy in acromegalic patients with diastolic dysfunction. Methods: Fourteen patients (7 males and 7 females) with the diagnosis of acromegaly and diastolic dysfunction confirmed by echocardiogram were studied. After six months of treatment with verapamil (240 mg/day) the echo-cardiographic parameters and the functional class (NYHA) of patients were reevaluated. Results: All patients showed an increased basal measurement of the cardiac mass (mean [percentiles 25-75]: 149 g/m2 [128-264]) and no improvement was observed after treatment (182 g/m2 [123-328]). Also, no improvement was found regarding the studied diastolic function parameters: E/A relationship of left ventricle (0.70 [0.54-0.83] versus 0.61 [0.54-0.86]) and isovolumetric relaxation time (146 [119-193] versus 120 [97-169]). A trend towards improvement was indeed found in the functional class, although no statistical differences were observed. Conclusion: Our results did not demonstrate a benefit derived from the treatment with verapamil upon the diastolic function in patients with acromegaly. |
| Databáze: | MEDLINE |
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