| Autor: |
Maliuk Vol I, Maliuk VI, Ovruts'ka ZH, Stechenko LO |
| Jazyk: |
ukrajinština |
| Zdroj: |
Ukrains'kyi biokhimichnyi zhurnal [Ukr Biokhim Zh] 1976 Jan-Feb; Vol. 48 (1), pp. 16-22. |
| Abstrakt: |
The effect of heparin on isolated rabbit heart mitochondria was studied in usual clinical (0.25 u/ml) and higher doses. Hepain concentration 0.25 u/ml stimulated respiration in the state 4, decreased ADP/O ratio and phosphorylation rate and did not affect mitochondria ultrastructure. Higher concentration caused two-phase changes in respiration-short-time stimulation with the following inhibition, oxidative phosphorylation (respiratory control, ADP/O, phosphorylation rate) was progressively depressed and decoupled. The mitochondria ultrastructure is changed under the influence of 1.25 u/ml and of higher doses; the external membrane lost its two-layer character, the crista were converted into a small granular mass. Concentration of 1.25 u/ml transformed many mitochondria into empty vesicles. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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