| Autor: |
Ianchiĭ RI; A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev., Bidzilia IuP, Hotsuliak IaM, Ianchiĭ OR, Hovorukha OV |
| Jazyk: |
ukrajinština |
| Zdroj: |
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2002; Vol. 48 (6), pp. 19-25. |
| Abstrakt: |
The effects of both arachidonic acid (AA) and inhibition of its metabolism on the antibody-induced changes in the mechanical contraction and action potentials of the isolated papillary muscles were studied. It has been shown that antibody-dependent induction of AA oxidation led to the initiation of Ca2+ entry through voltage-dependent Ca2+ channels of a myocyte. Inhibition of the lipoxygenase way of AA peroxidation prevented Ca2+ overload of cardiomyocytes more than inhibition of the cyclooxygenase way, but less than blocking Ca2+ channels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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