| Autor: |
El-Shewy KA; Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Hussien AM, El-Maghraby DF |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the Egyptian Society of Parasitology [J Egypt Soc Parasitol] 1999; Vol. 29 (1), pp. 281-9. |
| Abstrakt: |
An 18-20 kDa Cryptosporidum coproantigen (18-20 CCA), had been detected in the stool of infected humans and calves. A purified, electroeluted and concentrated 18-20 kDa antigen was tested in Ussing chamber, and electric parameters were tested before and after the addition of this antigen. A significant increase in the short circuit current (Isc) was detected. The enterotoxic effectof 18-20 kDa CCA, was time and dose dependent, heat labile, and Cl- dependent. The detected change in the short circuit current was not detected when the 18-20 kDa antigen wa incubated with its monospecific antibodies. These results indicate an enterotoxic activity of the 18-20 kDa antigen secreted from the released parasite and detected in stool of infected humans and calves. Additionally, they may help in developing an appropriate anti-secretory therapy for the intractable diarrhoea caused by cryptosporidiosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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