| Autor: |
Couto FD; Centro de Pesquisas Gonçalo Moniz/FIOCRUZ-Pathology and Molecular Biology Laboratory, Bahia, Brazil., De Albuquerque AB, Adorno EV, De Moura Neto JP, De Freitas Abbehusen L, De Oliveira JL, Dos Reis MG, De Souza Gonçalves M |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and laboratory haematology [Clin Lab Haematol] 2003 Feb; Vol. 25 (1), pp. 29-34. |
| DOI: |
10.1046/j.1365-2257.2003.00487.x |
| Abstrakt: |
alpha-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. alpha-thalassemia-23.7kb (alpha-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women - 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were alpha-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal alpha genes and those with alpha-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal alpha genes and alpha-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal alpha genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the alpha-Thal23.7kb genotype. The AC alpha-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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