Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Autor: Colletti SL; Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. steve_colletti@merck.com, Frie JL, Dixon EC, Singh SB, Choi BK, Scapin G, Fitzgerald CE, Kumar S, Nichols EA, O'Keefe SJ, O'Neill EA, Porter G, Samuel K, Schmatz DM, Schwartz CD, Shoop WL, Thompson CM, Thompson JE, Wang R, Woods A, Zaller DM, Doherty JB
Jazyk: angličtina
Zdroj: Journal of medicinal chemistry [J Med Chem] 2003 Jan 30; Vol. 46 (3), pp. 349-52.
DOI: 10.1021/jm025585h
Abstrakt: Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.
Databáze: MEDLINE