Effect of topical mitomycin on skin wound contraction.
| Autor: | Sewall GK; Division of Otolaryngology, Department of Surgery, University of Wisconsin Medical School, Madison, USA., Robertson KM, Connor NP, Heisey DM, Hartig GK |
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| Jazyk: | angličtina |
| Zdroj: | Archives of facial plastic surgery [Arch Facial Plast Surg] 2003 Jan-Feb; Vol. 5 (1), pp. 59-62. |
| DOI: | 10.1001/archfaci.5.1.59 |
| Abstrakt: | Objective: To evaluate the effect of different dosing regimens of mitomycin on skin wound contraction. Methods: Full-thickness skin wounds were created in 5 groups of hairless mice, which represented different dosing regimens or a sterile water control: A, control; B, mitomycin (0.5 mg/mL) applied immediately after creation of the lesion (day 1); C, mitomycin (1.0 mg/mL) applied on day 1; D, mitomycin (0.5 mg/mL) applied on days 1 and 3; and E, mitomycin (1.0 mg/mL) applied on days 1 and 3. Wound surface area was measured immediately after drug application (day 1), and thereafter every 3 to 5 days until day 29 by means of computer-assisted image analysis. Results: All dosing regimens of mitomycin application resulted in an initially exponential rate of wound contraction that was significantly slower than in the sterile water control group, with a significantly larger wound surface area on day 29. Wound area in the control group contracted approximately 9 times more rapidly than in the treatment groups. No difference was observed among the different dosing regimens. Conclusion: Application of mitomycin, at the lowest dose and frequency of application used in this study, resulted in improved outcomes with regard to contraction of full-thickness skin wounds. |
| Databáze: | MEDLINE |
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