Effect of intravenous propranolol on left ventricular apical ballooning without coronary artery stenosis (ampulla cardiomyopathy): three cases.

Autor: Kyuma M; Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan. kyuma@sapmed.ac.jp, Tsuchihashi K, Shinshi Y, Hase M, Nakata T, Ooiwa H, Abiru M, Hikita N, Adachi T, Shoji T, Fujise Y, Shimamoto K
Jazyk: angličtina
Zdroj: Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2002 Dec; Vol. 66 (12), pp. 1181-4.
DOI: 10.1253/circj.66.1181
Abstrakt: The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called 'takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did not have any intraventricular pressure gradients showed no improvement in the electrocardiographic and left ventricular wall motion abnormalities, the other 2 patients, who had significant intraventricular pressure gradients, did show improvement. Dynamic intraventricular obstruction might play a role in maintaining apical ballooning, at least, in patients exhibiting an intraventricular pressure gradient.
Databáze: MEDLINE