[Status of microcirculation and cardiodynamics in ischemic heart disease patients with decreased left ventricular fraction and their response to carvedilol].

Autor:	Vasil'ev AP, Strel'tsova NN, Gorbunova TIu
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2002; Vol. 74 (11), pp. 69-71.
Abstrakt:	Aim: Assessment of microcirculation in IHD patients at preclinical stage or in those with initial symptoms of cardiac failure, clarification of relationship between parameters of microcirculation and cardiodynamics. Material and Methods: A blind cross-over trial was made to compare skin microcirculation and cardiodynamic parameters in response to a short carvedilol course and beta-blocker anaprilin in 40 patients with ischemic heart disease with angina of effort (NYHA class I-IV, ejection fraction under 45%). Results: IHD with initial symptoms of cardiac failure had a congestion-spastic type of microcirculation defect. Microcirculatory picture and cardiodynamics were related. Conclusion: Compared to anaprilin therapy, treatment with carvedilol enhanced capillary blood flow and improved cardiodynamics.
Databáze:	MEDLINE
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