Non-invasive ventilation in motor neuron disease: current UK practice.
| Autor: | Bourke SC; University of Newcastle, Newcastle upon Tyne NE7 7DN, UK. sbourke@doctors.org.uk, Williams TL, Bullock RE, Gibson GJ, Shaw PJ |
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| Jazyk: | angličtina |
| Zdroj: | Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases [Amyotroph Lateral Scler Other Motor Neuron Disord] 2002 Sep; Vol. 3 (3), pp. 145-9. |
| DOI: | 10.1080/146608202760834157 |
| Abstrakt: | Objective: To evaluate the clinical application of non-invasive ventilation (NIV) in motor neuron disease (MND) in the UK. Method: We conducted a postal survey of the current clinical practice of all consultant neurologists in the UK, with a second mailing to non-responders after 6 weeks. The principal outcome measures assessed were: 1. the percentage of patients with MND receiving NIV, 2. access to a NIV service, 3. routine monitoring of respiratory function, and 4. influence of symptoms, respiratory function, rate of disease progression, level of disability and bulbar involvement on referral for NIV. Results: The response rate was 76%, 1719 new patients had been diagnosed in the preceding 12 months and a total of 2280 patients were under review. Of these, 126 were currently receiving NIV (5.5% of patients under review, estimated 2.6-3.5% of all MND patients). Most neurologists (172/265) had referred no patients for NIV in the preceding year, while three neurologists made 30% of all referrals nationally. Referral was based primarily on symptoms, and was influenced by the number of MND patients under review, level of disability, rate of disease progression and availability of a NIV service. Bulbar involvement was considered a relative contra-indication to NIV by 51% of responders. Conclusions: In the UK, few patients with MND are treated with NIV. There is marked variation in clinical practice. This may reflect uncertainty about the role of non-invasive ventilation in MND, and emphasizes the need for a randomized controlled trial to assess the impact of NIV on quality of life and survival. |
| Databáze: | MEDLINE |
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