| Autor: |
Hashmi SA; Department of Chemistry, Paul M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708, USA., Hu X, Immoos CE, Lee SJ, Grinstaff MW |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2002 Dec 26; Vol. 4 (26), pp. 4571-4. |
| DOI: |
10.1021/ol026704q |
| Abstrakt: |
[reaction: see text] A facile procedure for the incorporation of N-methyl phenothiazine as the terminal nucleoside in oligodeoxynucleotides is reported. The phenothiazine nucleoside analogue is synthesized and then incorporated into DNA using an automated DNA solid-phase synthesizer. Phenothiazine-labeled oligodeoxynucleotides form stable B-form duplexes with higher melting temperatures compared to unlabeled DNA duplexes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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