| Autor: |
Farinha NJ; Division of Hematology-Oncology, Hôpital Sainte-Justine, Montreal, Canada., Duval M, Wagner E, Champagne J, Lapointe N, Barrette S, Tapiero B, Busque L, Champagne MA |
| Jazyk: |
angličtina |
| Zdroj: |
Bone marrow transplantation [Bone Marrow Transplant] 2002 Dec; Vol. 30 (12), pp. 979-81. |
| DOI: |
10.1038/sj.bmt.1703719 |
| Abstrakt: |
The severe form of leukocyte adhesion deficiency type I (LAD-I) usually leads to death early in life. Allogeneic haematopoietic transplantation is the only cure. Unrelated transplantation has been reported only once. We describe three children with LAD-I transplanted with T cell non-depleted bone marrow from unrelated HLA-matched donors. All patients engrafted, one of them at second transplant. One patient developed grade I and one grade II acute GVHD. Two patients are alive, one of them with a decrease in CD11/CD18 expression. Early referral for HLA-matched unrelated BMT is a reasonable option for patients with LAD-I lacking an HLA-matched related donor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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