| Autor: |
Hu XE; Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040, USA. hu.xe@pg.com, Kim NK, Ledoussal B |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2002 Dec 12; Vol. 4 (25), pp. 4499-502. |
| DOI: |
10.1021/ol027019m |
| Abstrakt: |
[reaction: see text] trans-(3S)-Amino piperidines bearing various alkyl and aryl substituents at the C-4 position were synthesized via a ring-closing metathesis reaction. The absolute stereochemistry was controlled using a protected D-serine as a starting material. Stereoselective hydrogenation of allylamines provided trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines. This procedure presents the first method for the asymmetric synthesis of 4-substituted 3-amino piperidines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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