Salvage abdominoperineal resection in anal epidermoid cancer.

Autor: Nilsson PJ; Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden. per.nilsson@ersta.se, Svensson C, Goldman S, Glimelius B
Jazyk: angličtina
Zdroj: The British journal of surgery [Br J Surg] 2002 Nov; Vol. 89 (11), pp. 1425-9.
DOI: 10.1046/j.1365-2168.2002.02231.x
Abstrakt: Background: In the management of isolated locoregional failure after (chemo)radiation therapy for anal epidermoid cancer, salvage abdominoperineal resection (APR) is the treatment of choice. The results of a 15-year consecutive population-based series are reviewed.
Methods: Details of all patients with anal epidermoid cancer treated from 1985 to 2000 in the Stockholm Health Care Region were recorded prospectively. Among 308 patients with biopsy-proven anal epidermoid cancer, there have been 39 isolated locoregional failures after sphincter-preserving therapy. Thirty-five patients have undergone salvage APR. The medical records of these 35 patients were reviewed retrospectively with regard to surgical and oncological results.
Results: There were no postoperative deaths. There was considerable morbidity related to the perineal wound, with postoperative perineal infections in 13 patients and delayed healing beyond 3 months in 23 patients. Complications unrelated to the perineal wound were found in 13 patients. The crude 5-year survival rate for the 35 patients was 52 per cent (median follow-up 33 months). Patients with persistent disease fared significantly worse than those with locoregional recurrence (crude 5-year survival rate 33 versus 82 per cent; P < 0.05, log rank test).
Conclusion: Salvage APR in anal epidermoid cancer is associated with a high complication rate but may result in long-term survival.
Databáze: MEDLINE
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