Neurofibrillary changes after acute experimental lead poisoning.
| Autor: | Niklowitz WJ |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Neurology [Neurology] 1975 Oct; Vol. 25 (10), pp. 927-34. |
| DOI: | 10.1212/wnl.25.10.927 |
| Abstrakt: | Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200 A diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 A) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed. |
| Databáze: | MEDLINE |
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