| Autor: |
Garcia SB; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, São Paulo, Brazil. sbgarcia@fmrp.usp.br, Demarzo MM, Vinhadeli WS, Llorach-Velludo MA, Zoteli J, Herrero CF, Zucoloto S |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroscience letters [Neurosci Lett] 2002 Oct 04; Vol. 331 (1), pp. 66-8. |
| DOI: |
10.1016/s0304-3940(02)00832-7 |
| Abstrakt: |
The number of myenteric neurons may be reduced by topical serosal application of benzalkonium chloride (BAC). We studied the effects of ageing in the population of neurons that survive after the application of BAC. Ten treated and ten control animals were killed at intervals of 2, 6, 12 and 18 months after the surgery. We performed myenteric neurons counting in serially cut histological preparations of the descending colon. The control animals revealed a continuous loss of myenteric neurons number with increasing of age. Interestingly, contrary to control animals, the BAC-treated rats presented no neuron loss with ageing at any experimental time. The reasons for their survival with ageing could be related to a neuroplasticity phenomenon. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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